Cargando…

Combinatorial treatment with polyI:C and anti-IL6 enhances apoptosis and suppresses metastasis of lung cancer cells

Activation of TLR3 stimulates cancer cell apoptosis and triggers secretion of inflammatory cytokines. PolyI:C, a TLR3 agonist, activates immune cells and regresses metastatic lung cancer in vivo. Although polyI:C reportedly kills lung carcinomas, the mechanism remains elusive. Here, we demonstrated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lau, Wai Hoe, Zhu, Xiphias Ge, Ho, Shamaine Wei Ting, Chang, Shu Chun, Ding, Jeak Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464836/ https://www.ncbi.nlm.nih.gov/pubmed/28427199 http://dx.doi.org/10.18632/oncotarget.15862

Ejemplares similares

The IL-17 receptor IL-17RE mediates polyIC-induced exacerbation of experimental allergic asthma
por: Vella, Giovanna, et al.
Publicado: (2020)

Type I Interferon Drives Dendritic Cell Apoptosis via Multiple BH3-Only Proteins following Activation by PolyIC In Vivo
por: Fuertes Marraco, Silvia A., et al.
Publicado: (2011)

Suppression of polyi:c-inducible gene expression by EP3 in murine conjunctival epithelium
por: Ueta, Mayumi, et al.
Publicado: (2014)

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation
por: Ebihara, Takashi, et al.
Publicado: (2010)

Identification of a polyI:C-inducible membrane protein that participates in dendritic cell–mediated natural killer cell activation
por: Ebihara, Takashi, et al.
Publicado: (2015)

Organoids containing neural-like cells derived from chicken iPSCs respond to poly:IC through the RLR family
por: Katayama, Masafumi, et al.
Publicado: (2023)

RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation
por: Schmidt, Susanne V., et al.
Publicado: (2015)

Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice
por: AZUMA, Yasu-Taka, et al.
Publicado: (2020)

Targeting the Immune System to Fight Cancer Using Chemical Receptor Homing Vectors Carrying Polyinosine/Cytosine (PolyIC)
por: Levitzki, Alexander
Publicado: (2012)

Correction: RIPK3 expression in cervical cancer cells is required for PolyIC-induced necroptosis, IL-1α release, and efficient paracrine dendritic cell activation
por: Schmidt, Susanne V., et al.
Publicado: (2019)

Targeting polyIC to EGFR over-expressing cells using a dsRNA binding protein domain tethered to EGF
por: Edinger, Nufar, et al.
Publicado: (2016)

P11-15. Induction of a mucosal immune response to HIV after systemic immunization with poly(lactic acid) nanoparticles formulated with gag antigen and polyI:C
por: Primard, C, et al.
Publicado: (2009)

Lipopolysaccharide Attenuates Induction of Proallergic Cytokines, Thymic Stromal Lymphopoietin, and Interleukin 33 in Respiratory Epithelial Cells Stimulated with PolyI:C and Human Parechovirus
por: Lin, Tsang-Hsiung, et al.
Publicado: (2016)

PolyI:C Upregulated CCR5 and Promoted THP-1-Derived Macrophage Chemotaxis via TLR3/JMJD1A Signalling
por: Yu, Xiaoxiao, et al.
Publicado: (2020)

PolyI:C attenuates transforming growth factor‐β signaling to induce cytostasis of surrounding cells by secreted factors in triple‐negative breast cancer
por: Tamura, Yusuke, et al.
Publicado: (2021)

Differential utilization of NF-kappaB RELA and RELB in response to extracellular versus intracellular polyIC stimulation in HT1080 cells
por: Yun, James J, et al.
Publicado: (2011)

Changes in H3K27ac at Gene Regulatory Regions in Porcine Alveolar Macrophages Following LPS or PolyIC Exposure
por: Herrera-Uribe, Juber, et al.
Publicado: (2020)

AddaVax Formulated with PolyI:C as a Potential Adjuvant of MDCK-based Influenza Vaccine Enhances Local, Cellular, and Antibody Protective Immune Response in Mice
por: Nian, Xuanxuan, et al.
Publicado: (2021)

Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells
por: Azuma, Masahiro, et al.
Publicado: (2012)

TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model
por: Huang, Chaohao, et al.
Publicado: (2019)

The immune responses of HLA-A*0201 restricted SARS-CoV S peptide-specific CD8(+) T cells are augmented in varying degrees by CpG ODN, PolyI:C and R848
por: Zhao, Kai, et al.
Publicado: (2011)

Dissection of gastric cancer heterogeneity for precision oncology
por: Ho, Shamaine Wei Ting, et al.
Publicado: (2019)

Human FBXL8 Is a Novel E3 Ligase Which Promotes BRCA Metastasis by Stimulating Pro-Tumorigenic Cytokines and Inhibiting Tumor Suppressors
por: Chang, Shu-Chun, et al.
Publicado: (2020)

JP1 normalizes tumor vasculature to suppress metastasis and facilitate drug delivery by inhibiting IL-8
por: Cui, Jiahua, et al.
Publicado: (2023)

Iterative Methods in Combinatorial Optimization
por: Lau, Lap-Chi, et al.
Publicado: (2011)

Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium
por: Chang, Gue Su, et al.
Publicado: (2012)

Cabozantinib and IL-27 combinatorial therapy for bone-metastatic prostate cancer
por: Kumar, Shreya, et al.
Publicado: (2023)

Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat
por: Chi, Jingyi, et al.
Publicado: (2021)

Handbook of combinatorial optimization
por: Du, Ding-Zhu, et al.
Publicado: (1999)

Combinatorial network theory
por: Du, Ding-Zhu, et al.
Publicado: (1996)

Nonlinear combinatorial optimization
por: Du, Ding-Zhu, et al.
Publicado: (2019)

Handbook of combinatorial optimization
por: Pardalos, Panos, et al.
Publicado: (2013)

Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis
por: Yin, Shu-Yi, et al.
Publicado: (2016)

Combinatorial design of calcium meta phosphate poly(vinyl alcohol) bone-like biocomposites
por: Nkhwa, Shathani, et al.
Publicado: (2018)

Targeting TIGIT Inhibits Bladder Cancer Metastasis Through Suppressing IL-32
por: Wu, Kang, et al.
Publicado: (2022)

Erratum: Induction of IL-25 secretion from tumour-associated fibroblasts suppresses mammary tumour metastasis
por: Yin, Shu-Yi, et al.
Publicado: (2016)

Hesperetin ameliorates glioblastoma by inhibiting proliferation, inducing apoptosis, and suppressing metastasis
por: Cheng, Qian, et al.
Publicado: (2022)

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?
por: Ang, Zhiwei, et al.
Publicado: (2016)

MEK1/2 Inhibitors Unlock the Constrained Interferon Response in Macrophages Through IRF1 Signaling
por: Yang, Lei, et al.
Publicado: (2019)

Binary combinatorial scanning reveals potent poly-alanine-substituted inhibitors of protein-protein interactions
por: Ye, Xiyun, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vnli4ofbpji64ikcbp0vhu0spa