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Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1
Glioblastoma (GBM) is the most common brain tumor with poor survival rate. Our results show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult and pediatric glioblastoma cell lines with IC(50) ranging 2–5 μM after 72 hours of treatment and induced apoptosis. Penf...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals LLC
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464842/ https://www.ncbi.nlm.nih.gov/pubmed/28380428 http://dx.doi.org/10.18632/oncotarget.16515 |