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Penfluridol suppresses glioblastoma tumor growth by Akt-mediated inhibition of GLI1

Glioblastoma (GBM) is the most common brain tumor with poor survival rate. Our results show that penfluridol, an antipsychotic drug significantly reduced the survival of ten adult and pediatric glioblastoma cell lines with IC(50) ranging 2–5 μM after 72 hours of treatment and induced apoptosis. Penf...

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Detalles Bibliográficos
Autores principales:	Ranjan, Alok, Srivastava, Sanjay K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464842/ https://www.ncbi.nlm.nih.gov/pubmed/28380428 http://dx.doi.org/10.18632/oncotarget.16515

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