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Pharmacologic targeting ERK1/2 attenuates the development and progression of hyperuricemic nephropathy in rats
The pathogenesis of hyperuricemia-induced chronic kidney disease is largely unknown. In this study, we investigated whether extracellular signal–regulated kinases1/2 (ERK1/2) would contribute to the development of hyperuricemic nephropathy (HN). In a rat model of HN induced by feeding mixture of ade...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464913/ https://www.ncbi.nlm.nih.gov/pubmed/28442634 http://dx.doi.org/10.18632/oncotarget.16995 |