Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1

Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming growth factor β (TGF-β) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (HHT1) and involved in tumor angiogenesis and preeclampsia. Here, we present crystal structures of the ectodomain of huma...

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Detalles Bibliográficos
Autores principales: Saito, Takako, Bokhove, Marcel, Croci, Romina, Zamora-Caballero, Sara, Han, Ling, Letarte, Michelle, de Sanctis, Daniele, Jovine, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464963/
https://www.ncbi.nlm.nih.gov/pubmed/28564608
http://dx.doi.org/10.1016/j.celrep.2017.05.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464963/
https://www.ncbi.nlm.nih.gov/pubmed/28564608
http://dx.doi.org/10.1016/j.celrep.2017.05.011

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