Targeting Bacillus anthracis toxicity with a genetically selected inhibitor of the PA/CMG2 protein-protein interaction

The protein-protein interaction between the human CMG2 receptor and the Bacillus anthracis protective antigen (PA) is essential for the transport of anthrax lethal and edema toxins into human cells. We used a genetically encoded high throughput screening platform to screen a SICLOPPS library of 3.2...

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Detalles Bibliográficos
Autores principales: Male, Abigail L., Forafonov, Fedor, Cuda, Francesco, Zhang, Gong, Zheng, Siqi, Oyston, Petra C. F., Chen, Peng R., Williamson, E. Diane, Tavassoli, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465072/
https://www.ncbi.nlm.nih.gov/pubmed/28596569
http://dx.doi.org/10.1038/s41598-017-03253-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465072/
https://www.ncbi.nlm.nih.gov/pubmed/28596569
http://dx.doi.org/10.1038/s41598-017-03253-3

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