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Microenvironmental cooperation promotes early spread and bistability of a Warburg-like phenotype

We introduce an in silico model for the initial spread of an aberrant phenotype with Warburg-like overflow metabolism within a healthy homeostatic tissue in contact with a nutrient reservoir (the blood), aimed at characterizing the role of the microenvironment for aberrant growth. Accounting for cel...

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Detalles Bibliográficos
Autores principales: Fernandez-de-Cossio-Diaz, Jorge, De Martino, Andrea, Mulet, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465218/
https://www.ncbi.nlm.nih.gov/pubmed/28596605
http://dx.doi.org/10.1038/s41598-017-03342-3