Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation

Orexin neurons originating in the perifornical and lateral hypothalamic area are highly reactive to anxiogenic stimuli and have strong projections to anxiety and panic-associated circuitry. Recent studies support a role for the orexin system and in particular the orexin 1 receptor (OX1R) in coordina...

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Detalles Bibliográficos
Autores principales: Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D., Shekhar, Anantha, Johnson, Philip L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465257/
https://www.ncbi.nlm.nih.gov/pubmed/28649201
http://dx.doi.org/10.3389/fphar.2017.00357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465257/
https://www.ncbi.nlm.nih.gov/pubmed/28649201
http://dx.doi.org/10.3389/fphar.2017.00357

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