Detection of a genetic footprint of the sofosbuvir resistance-associated substitution S282T after HCV treatment failure

BACKGROUND: The major resistance-associated substitution for sofosbuvir (S282T) in HCV NS5B causes severe viral fitness costs and rapidly reverts back to prototype in the absence of selection pressure. Accordingly, resistance against sofosbuvir is rarely detected even in patients after treatment fai...

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Detalles Bibliográficos
Autores principales: Walker, Andreas, Filke, Sandra, Lübke, Nadine, Obermeier, Martin, Kaiser, Rolf, Häussinger, Dieter, Timm, Jörg, Bock, Hans H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465446/
https://www.ncbi.nlm.nih.gov/pubmed/28595606
http://dx.doi.org/10.1186/s12985-017-0779-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465446/
https://www.ncbi.nlm.nih.gov/pubmed/28595606
http://dx.doi.org/10.1186/s12985-017-0779-4

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