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T cells bearing anti-CD19 and/or anti-CD38 chimeric antigen receptors effectively abrogate primary double-hit lymphoma cells

Patients with B cell lymphomas bearing MYC translocation combined with translocation involving other genes, such as BCL2, BCL3, or BCL6, defined as double-hit lymphoma (DHL), have a poor prognosis. Recent studies expanded the concept to include double-expressing lymphoma (DEL) that co-overexpresses...

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Detalles Bibliográficos
Autores principales: Mihara, Keichiro, Yoshida, Tetsumi, Takei, Yoshifumi, Sasaki, Naomi, Takihara, Yoshihiro, Kuroda, Junya, Ichinohe, Tatsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465447/
https://www.ncbi.nlm.nih.gov/pubmed/28595585
http://dx.doi.org/10.1186/s13045-017-0488-x