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A membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel

General anesthetics exert their effects on the central nervous system by acting on ion channels, most notably pentameric ligand-gated ion channels. Although numerous studies have focused on pentameric ligand-gated ion channels, the details of anesthetic binding and channel modulation are still debat...

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Detalles Bibliográficos
Autores principales: Arcario, Mark J., Mayne, Christopher G., Tajkhorshid, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465477/
https://www.ncbi.nlm.nih.gov/pubmed/28420728
http://dx.doi.org/10.1074/jbc.M117.780197