Design of new acid-activated cell-penetrating peptides for tumor drug delivery

TH(AGYLLGHINLHHLAHL(Aib)HHIL-NH(2)), a histidine-rich, cell-penetrating peptide with acid-activated pH response, designed and synthesized by our group, can effectively target tumor tissues with an acidic extracellular environment. Since the protonating effect of histidine plays a critical role in th...

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Detalles Bibliográficos
Autores principales: Yao, Jia, Ma, Yinyun, Zhang, Wei, Li, Li, Zhang, Yun, Zhang, Li, Liu, Hui, Ni, Jingman, Wang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465999/
https://www.ncbi.nlm.nih.gov/pubmed/28603674
http://dx.doi.org/10.7717/peerj.3429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465999/
https://www.ncbi.nlm.nih.gov/pubmed/28603674
http://dx.doi.org/10.7717/peerj.3429

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