Modification of a bi-functional diguanylate cyclase-phosphodiesterase to efficiently produce cyclic diguanylate monophosphate

Cyclic-diGMP is a bacterial messenger that regulates many physiological processes, including many attributed to pathogenicity. Bacteria synthesize cyclic-diGMP from GTP using diguanylate cyclases; its hydrolysis is catalyzed by phosphodiesterases. Here we report the over-expression and purification...

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Detalles Bibliográficos
Autores principales: Nesbitt, Natasha M., Arora, Dhruv P., Johnson, Roger A., Boon, Elizabeth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466042/
https://www.ncbi.nlm.nih.gov/pubmed/28626712
http://dx.doi.org/10.1016/j.btre.2015.04.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466042/
https://www.ncbi.nlm.nih.gov/pubmed/28626712
http://dx.doi.org/10.1016/j.btre.2015.04.008

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