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4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method

We developed a four‐dimensional volumetric modulated arc therapy (4D VMAT) planning technique for moving targets using a direct aperture deformation (DAD) method and investigated its feasibility for clinical use. A 3D VMAT plan was generated on a reference phase of a 4D CT dataset. The plan was comp...

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Detalles Bibliográficos
Autores principales: Zhang, Yongqian, Yang, Yong, Fu, Weihua, Li, Xiang, Li, Tianfang, Heron, Dwight E., Huq, M. Saiful.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466079/
https://www.ncbi.nlm.nih.gov/pubmed/28300367
http://dx.doi.org/10.1002/acm2.12053
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author Zhang, Yongqian
Yang, Yong
Fu, Weihua
Li, Xiang
Li, Tianfang
Heron, Dwight E.
Huq, M. Saiful.
author_facet Zhang, Yongqian
Yang, Yong
Fu, Weihua
Li, Xiang
Li, Tianfang
Heron, Dwight E.
Huq, M. Saiful.
author_sort Zhang, Yongqian
collection PubMed
description We developed a four‐dimensional volumetric modulated arc therapy (4D VMAT) planning technique for moving targets using a direct aperture deformation (DAD) method and investigated its feasibility for clinical use. A 3D VMAT plan was generated on a reference phase of a 4D CT dataset. The plan was composed of a set of control points including the beam angle, MLC apertures and weights. To generate the 4D VMAT plan, these control points were assigned to the closest respiratory phases using the temporal information of the gantry angle and respiratory curve. Then, a DAD algorithm was used to deform the beam apertures at each control point to the corresponding phase to compensate for the tumor motion and shape changes. Plans for a phantom and five lung cases were included in this study to evaluate the proposed technique. Dosimetric comparisons were performed between 4D and 3D VMAT plans. Plan verification was implemented by delivering the 4D VMAT plans on a moving QUASAR™ phantom driven with patient‐specific respiratory curves. The phantom study showed that the 4D VMAT plan generated with the DAD method was comparable to the ideal 3D VMAT plan. DVH comparisons indicated that the planning target volume (PTV) coverages and minimum doses were nearly invariant, and no significant difference in lung dosimetry was observed. Patient studies revealed that the GTV coverage was nearly the same; although the PTV coverage dropped from 98.8% to 94.7%, and the mean dose decreased from 64.3 to 63.8 Gy on average. For the verification measurements, the average gamma index pass rate was 98.6% and 96.5% for phantom 3D and 4D VMAT plans with 3%/3 mm criteria. For patient plans, the average gamma pass rate was 96.5% (range 94.5–98.5%) and 95.2% (range 94.1–96.1%) for 3D and 4D VMAT plans. The proposed 4D VMAT planning technique using the DAD method is feasible to incorporate the intra‐fraction organ motion and shape change into a 4D VMAT planning. It has great potential to provide high plan quality and delivery efficiency for moving targets.
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spelling pubmed-54660792017-06-09 4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method Zhang, Yongqian Yang, Yong Fu, Weihua Li, Xiang Li, Tianfang Heron, Dwight E. Huq, M. Saiful. J Appl Clin Med Phys Radiation Oncology Physics We developed a four‐dimensional volumetric modulated arc therapy (4D VMAT) planning technique for moving targets using a direct aperture deformation (DAD) method and investigated its feasibility for clinical use. A 3D VMAT plan was generated on a reference phase of a 4D CT dataset. The plan was composed of a set of control points including the beam angle, MLC apertures and weights. To generate the 4D VMAT plan, these control points were assigned to the closest respiratory phases using the temporal information of the gantry angle and respiratory curve. Then, a DAD algorithm was used to deform the beam apertures at each control point to the corresponding phase to compensate for the tumor motion and shape changes. Plans for a phantom and five lung cases were included in this study to evaluate the proposed technique. Dosimetric comparisons were performed between 4D and 3D VMAT plans. Plan verification was implemented by delivering the 4D VMAT plans on a moving QUASAR™ phantom driven with patient‐specific respiratory curves. The phantom study showed that the 4D VMAT plan generated with the DAD method was comparable to the ideal 3D VMAT plan. DVH comparisons indicated that the planning target volume (PTV) coverages and minimum doses were nearly invariant, and no significant difference in lung dosimetry was observed. Patient studies revealed that the GTV coverage was nearly the same; although the PTV coverage dropped from 98.8% to 94.7%, and the mean dose decreased from 64.3 to 63.8 Gy on average. For the verification measurements, the average gamma index pass rate was 98.6% and 96.5% for phantom 3D and 4D VMAT plans with 3%/3 mm criteria. For patient plans, the average gamma pass rate was 96.5% (range 94.5–98.5%) and 95.2% (range 94.1–96.1%) for 3D and 4D VMAT plans. The proposed 4D VMAT planning technique using the DAD method is feasible to incorporate the intra‐fraction organ motion and shape change into a 4D VMAT planning. It has great potential to provide high plan quality and delivery efficiency for moving targets. John Wiley and Sons Inc. 2017-03-06 /pmc/articles/PMC5466079/ /pubmed/28300367 http://dx.doi.org/10.1002/acm2.12053 Text en © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Zhang, Yongqian
Yang, Yong
Fu, Weihua
Li, Xiang
Li, Tianfang
Heron, Dwight E.
Huq, M. Saiful.
4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method
title 4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method
title_full 4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method
title_fullStr 4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method
title_full_unstemmed 4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method
title_short 4D VMAT planning and verification technique for dynamic tracking using a direct aperture deformation (DAD) method
title_sort 4d vmat planning and verification technique for dynamic tracking using a direct aperture deformation (dad) method
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466079/
https://www.ncbi.nlm.nih.gov/pubmed/28300367
http://dx.doi.org/10.1002/acm2.12053
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