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The dynamic role of autophagy and MAPK signaling in determining cell fate under cisplatin stress in osteosarcoma cells

Osteosarcoma (OS) is an aggressive bone malignancy commonly observed in children and adolescents. Sub-optimal therapy for years has irretrievably compromised the chances of OS patient survival; also, lack of extensive research on this rare disease has hindered therapeutic development. Cisplatin, a c...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sudeshna, Dash, Subhra, Lohitesh, K., Chowdhury, Rajdeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466322/
https://www.ncbi.nlm.nih.gov/pubmed/28598976
http://dx.doi.org/10.1371/journal.pone.0179203