Identifying pathogenicity of human variants via paralog-based yeast complementation

To better understand the health implications of personal genomes, we now face a largely unmet challenge to identify functional variants within disease-associated genes. Functional variants can be identified by trans-species complementation, e.g., by failure to rescue a yeast strain bearing a mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Fan, Sun, Song, Tan, Guihong, Costanzo, Michael, Hill, David E., Vidal, Marc, Andrews, Brenda J., Boone, Charles, Roth, Frederick P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466341/
https://www.ncbi.nlm.nih.gov/pubmed/28542158
http://dx.doi.org/10.1371/journal.pgen.1006779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466341/
https://www.ncbi.nlm.nih.gov/pubmed/28542158
http://dx.doi.org/10.1371/journal.pgen.1006779

Ejemplares similares