Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury

Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for mercurials. Hg exposure results in GSH depletion...

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Detalles Bibliográficos
Autores principales: Branco, Vasco, Coppo, Lucia, Solá, Susana, Lu, Jun, Rodrigues, Cecília M.P., Holmgren, Arne, Carvalho, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466585/
https://www.ncbi.nlm.nih.gov/pubmed/28600984
http://dx.doi.org/10.1016/j.redox.2017.05.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466585/
https://www.ncbi.nlm.nih.gov/pubmed/28600984
http://dx.doi.org/10.1016/j.redox.2017.05.024

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