Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing os...

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Detalles Bibliográficos
Autores principales: Taverna, Simona, Pucci, Marzia, Giallombardo, Marco, Di Bella, Maria Antonietta, Santarpia, Mariacarmela, Reclusa, Pablo, Gil-Bazo, Ignacio, Rolfo, Christian, Alessandro, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466625/
https://www.ncbi.nlm.nih.gov/pubmed/28600504
http://dx.doi.org/10.1038/s41598-017-03460-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466625/
https://www.ncbi.nlm.nih.gov/pubmed/28600504
http://dx.doi.org/10.1038/s41598-017-03460-y

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