Cargando…

Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. The majority of patients are diagnosed in advanced disease stage. Bone metastasis is the most frequent complication in NSCLC resulting in osteolytic lesions. The perfect balance between bone-resorbing os...

Descripción completa

Detalles Bibliográficos
Autores principales:	Taverna, Simona, Pucci, Marzia, Giallombardo, Marco, Di Bella, Maria Antonietta, Santarpia, Mariacarmela, Reclusa, Pablo, Gil-Bazo, Ignacio, Rolfo, Christian, Alessandro, Riccardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466625/ https://www.ncbi.nlm.nih.gov/pubmed/28600504 http://dx.doi.org/10.1038/s41598-017-03460-y

Ejemplares similares

EML4-ALK translocation identification in RNA exosomal cargo (ExoALK) in NSCLC patients: a novel role for liquid biopsy
por: Reclusa, Pablo, et al.
Publicado: (2019)

Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21
por: Taverna, Simona, et al.
Publicado: (2015)

Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via exosomal miR-21
por: Taverna, Simona, et al.
Publicado: (2016)

Exosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: critical analysis of evidence and potential role in clinical practice
por: Taverna, Simona, et al.
Publicado: (2016)

Improving extracellular vesicles visualization: From static to motion
por: Reclusa, Pablo, et al.
Publicado: (2020)

Multiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis
por: Raimondo, Stefania, et al.
Publicado: (2019)

Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need
por: Pretelli, Giulia, et al.
Publicado: (2023)

Exosomal shuttling of miR-126 in endothelial cells modulates adhesive and migratory abilities of chronic myelogenous leukemia cells
por: Taverna, Simona, et al.
Publicado: (2014)

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation
por: Raimondi, Lavinia, et al.
Publicado: (2015)

Microglial-stimulation of glioma invasion involves the EGFR ligand amphiregulin
por: Coniglio, Salvatore J., et al.
Publicado: (2021)

Immunotherapeutic Advances for NSCLC
por: Massafra, Marco, et al.
Publicado: (2021)

Impact of epidermal growth factor receptor (EGFR) activating mutations and their targeted treatment in the prognosis of stage IV non-small cell lung cancer (NSCLC) patients harboring liver metastasis
por: Castañón, Eduardo, et al.
Publicado: (2015)

The Amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes
por: Raugh, Arielle, et al.
Publicado: (2023)

The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes
por: Raugh, Arielle, et al.
Publicado: (2023)

cMET in NSCLC: Can We Cut off the Head of the Hydra? From the Pathway to the Resistance
por: Van Der Steen, Nele, et al.
Publicado: (2015)

Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity
por: Schillaci, Odessa, et al.
Publicado: (2017)

Oncogenic signaling in amphiregulin and EGFR‐expressing PTEN‐null human breast cancer
por: Kappler, Christiana S., et al.
Publicado: (2014)

Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and Matrix Metalloproteinases
por: Platen, Christopher, et al.
Publicado: (2018)

Amphiregulin Regulates Melanocytic Senescence
por: Pommer, Michaela, et al.
Publicado: (2021)

Targeting MET in Non-Small Cell Lung Cancer (NSCLC): A New Old Story?
por: Spagnolo, Calogera Claudia, et al.
Publicado: (2023)

Detection of epidermal growth factor receptor (EGFR) mutations from preoperative circulating tumor DNA (ctDNA) as a prognostic predictor for stage I–III non-small cell lung cancer (NSCLC) patients with baseline tissue EGFR mutations
por: Guo, Kai, et al.
Publicado: (2021)

Spotlight on ceritinib in the treatment of ALK+ NSCLC: design, development and place in therapy
por: Santarpia, Mariacarmela, et al.
Publicado: (2017)

Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and the Bcl-2 Protein Family
por: Platen, Christopher, et al.
Publicado: (2019)

Unexpected responses to EGFR inhibition in NSCLC
por: Stella, Giulia M., et al.
Publicado: (2015)

Coregulation of pathways in lung cancer patients with EGFR mutation: therapeutic opportunities
por: Rosell, Rafael, et al.
Publicado: (2021)

Integrin-linked kinase (ILK) and src homology 2 domain-containing phosphatase 2 (SHP2): Novel targets in EGFR-mutation positive non-small cell lung cancer (NSCLC)
por: Karachaliou, Niki, et al.
Publicado: (2018)

Autocrine action of amphiregulin in a colon carcinoma cell line and immunocytochemical localization of amphiregulin in human colon
Publicado: (1992)

Immunotherapy in Early-Stage Non-Small Cell Lung Cancer (NSCLC): Current Evidence and Perspectives
por: Lazzari, Chiara, et al.
Publicado: (2023)

Circulating tumor DNA accurately predicts disease progression and genotype alterations in postoperative adjuvant EGFR-TKI resistance: a case report
por: Zeng, Zhen, et al.
Publicado: (2022)

Expression of Amphiregulin in Enchondromas and Central Chondrosarcomas
por: Losada, Daniele Moraes, et al.
Publicado: (2021)

Tumor immune microenvironment characterization and response to anti-PD-1 therapy
por: Santarpia, Mariacarmela, et al.
Publicado: (2015)

Amphiregulin-EGFR Signaling Mediates the Migration of Bone Marrow Mesenchymal Progenitors toward PTH-Stimulated Osteoblasts and Osteocytes
por: Zhu, Ji, et al.
Publicado: (2012)

TAZ sensitizes EGFR wild-type non-small-cell lung cancer to gefitinib by promoting amphiregulin transcription
por: Yuan, Weiwei, et al.
Publicado: (2019)

Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19
por: Maranatha, Daniel, et al.
Publicado: (2022)

Amphiregulin Mediates Estrogen, Progesterone, and EGFR Signaling in the Normal Rat Mammary Gland and in Hormone-Dependent Rat Mammary Cancers
por: Kariagina, Anastasia, et al.
Publicado: (2010)

Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells
por: Cheng, Wun-Hao, et al.
Publicado: (2022)

Stress-Induced Neuroprotective Effects of Epiregulin and Amphiregulin
por: Zhan, Libin, et al.
Publicado: (2015)

Blood and Salivary Amphiregulin Levels as Biomarkers for Asthma
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2020)

Erratum for: Expression of Amphiregulin in Enchondromas and Central Chondrosarcomas
Publicado: (2021)

Exosome-Bound WD Repeat Protein Monad Inhibits Breast Cancer Cell Invasion by Degrading Amphiregulin mRNA
por: Saeki, Makio, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vsmg4ig0b3pnc2c19sdbimspnc