Promoter hypermethylation inactivates CDKN2A, CDKN2B and RASSF1A genes in sporadic parathyroid adenomas

Cyclin D1, a G1-S phase regulator, is upregulated in parathyroid adenomas. Since cyclin-dependent kinase (CDK) inhibitors, CDKN2A and CDKN2B, and RASSF1A (Ras-association domain family 1, isoform A) are involved in G1-S phase arrest and act as potential tumor suppressor genes, we aimed to study pote...

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Detalles Bibliográficos
Autores principales: Arya, Ashutosh Kumar, Bhadada, Sanjay Kumar, Singh, Priyanka, Sachdeva, Naresh, Saikia, Uma Nahar, Dahiya, Divya, Behera, Arunanshu, Bhansali, Anil, Rao, Sudhaker D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466668/
https://www.ncbi.nlm.nih.gov/pubmed/28600574
http://dx.doi.org/10.1038/s41598-017-03143-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466668/
https://www.ncbi.nlm.nih.gov/pubmed/28600574
http://dx.doi.org/10.1038/s41598-017-03143-8

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