PI3Kδ inhibition elicits anti-leukemic effects through Bim-dependent apoptosis

PI3Kδ plays pivotal roles in the maintenance, proliferation and survival of malignant B-lymphocytes. Although not curative, PI3Kδ inhibitors (PI3Kδi) demonstrate impressive clinical efficacy and, alongside other signaling inhibitors, are revolutionizing the treatment of hematological malignancies. H...

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Detalles Bibliográficos
Autores principales: Carter, M J, Cox, K L, Blakemore, S J, Turaj, A H, Oldham, R J, Dahal, L N, Tannheimer, S, Forconi, F, Packham, G, Cragg, M S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467045/
https://www.ncbi.nlm.nih.gov/pubmed/27843137
http://dx.doi.org/10.1038/leu.2016.333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467045/
https://www.ncbi.nlm.nih.gov/pubmed/27843137
http://dx.doi.org/10.1038/leu.2016.333

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