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Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded
Our lack of total understanding of the intricacies of how enzymes behave has constrained our ability to robustly engineer substrate specificity. Furthermore, the mechanisms of natural evolution leading to improved or novel substrate specificities are not wholly defined. Here we generate near-compreh...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467163/ https://www.ncbi.nlm.nih.gov/pubmed/28585537 http://dx.doi.org/10.1038/ncomms15695 |