Cargando…

Efficient Divergent Synthesis of New Immunostimulant 4″-Modified α-Galactosylceramide Analogues

[Image: see text] A synthesis strategy for the swift generation of 4″-modified α-galactosylceramide (α-GalCer) analogues is described, establishing a chemical platform to comprehensively investigate the structure–activity relationships (SAR) of this understudied glycolipid part. The strategy relies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Janssens, Jonas, Decruy, Tine, Venken, Koen, Seki, Toshiyuki, Krols, Simon, Van der Eycken, Johan, Tsuji, Moriya, Elewaut, Dirk, Van Calenbergh, Serge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467197/ https://www.ncbi.nlm.nih.gov/pubmed/28626526 http://dx.doi.org/10.1021/acsmedchemlett.7b00107

Ejemplares similares

Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d
por: Guillaume, Joren, et al.
Publicado: (2017)

Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α-Galactosylceramide
por: Schmieg, John, et al.
Publicado: (2003)

An In Silico Approach for Modelling T-Helper Polarizing iNKT Cell Agonists
por: De Spiegeleer, Anton, et al.
Publicado: (2014)

MAIT Cells Come to the Rescue in Cancer Immunotherapy?
por: Lukasik, Zuzanna, et al.
Publicado: (2020)

It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells
por: Mortier, Céline, et al.
Publicado: (2018)

Synthesis and Immunological Activity of Novel Oligo(ethylene glycol) Analogues of α-Galactosylceramide
por: Pawar, Mithun S., et al.
Publicado: (2022)

Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?
por: Favreau, Mérédis, et al.
Publicado: (2016)

Crossing the boundaries: IL-23 and its role in linking inflammation of the skin, gut and joints
por: Łukasik, Zuzanna, et al.
Publicado: (2021)

Natural Killer T Cell Ligand α-Galactosylceramide Enhances Protective Immunity Induced by Malaria Vaccines
por: Gonzalez-Aseguinolaza, Gloria, et al.
Publicado: (2002)

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients
por: Venken, Koen, et al.
Publicado: (2019)

Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141(+) Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8(+) T Cell Response in Human Immune System Mice
por: Huang, Jing, et al.
Publicado: (2020)

Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus
por: Bouton, Jakob, et al.
Publicado: (2018)

Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice
por: Uchida, Takahiro, et al.
Publicado: (2018)

Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells
Publicado: (1995)

New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma
por: Verhoeven, Jeroen, et al.
Publicado: (2019)

In vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses
por: Beterams, Annelore, et al.
Publicado: (2022)

6-Methyl-7-deazapurine nucleoside analogues as broad-spectrum antikinetoplastid agents
por: Lin, Cai, et al.
Publicado: (2021)

Immunostimulation and Immunoinhibition of Premalignant Lesions
por: Prehn, Richmond T
Publicado: (2007)

Editorial: Vaccines and Immunostimulants for Finfish
por: Munang'andu, Hetron M., et al.
Publicado: (2020)

Nucleoside analogues for the treatment of animal trypanosomiasis
por: Mabille, Dorien, et al.
Publicado: (2022)

A multiparameter approach to monitor disease activity in collagen-induced arthritis
por: Seeuws, Sylvie, et al.
Publicado: (2010)

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor
por: Li, Wenjin, et al.
Publicado: (2020)

ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
por: Krols, Michiel, et al.
Publicado: (2016)

Humoral immunostimulation. IV. Role of complement
Publicado: (1975)

Phytol-Derived Novel Isoprenoid Immunostimulants
por: Chowdhury, Roshni Roy, et al.
Publicado: (2012)

Immunostimulant Effect of Egyptian Propolis in Rabbits
por: Nassar, Somya A., et al.
Publicado: (2012)

Immunostimulating Effects of Extract of Acanthopanax sessiliflorus
por: Kim, Jung-Hoon, et al.
Publicado: (2013)

Effects of interleukin-2 in immunostimulation and immunosuppression
por: Pol, Jonathan G., et al.
Publicado: (2019)

Immunostimulants in respiratory diseases: focus on Pidotimod
por: Puggioni, Francesca, et al.
Publicado: (2019)

α‐Galactosylceramide‐activated murine NK1.1(+) invariant‐NKT cells in the myometrium induce miscarriages in mice
por: Ichikawa, Tomoko, et al.
Publicado: (2016)

Glucosylceramide and galactosylceramide, small glycosphingolipids with significant impact on health and disease
por: Reza, Safoura, et al.
Publicado: (2021)

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids
por: Govindarajan, Srinath, et al.
Publicado: (2020)

Immunostimulation-Mediated Anti-tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained Under ‘Vigorous’ Condition
por: Seki, Takahiro, et al.
Publicado: (2010)

Revisiting immunosurveillance and immunostimulation: Implications for cancer immunotherapy
por: Ichim, Christine V
Publicado: (2005)

Drug Delivery–mediated Control of RNA Immunostimulation
por: Nguyen, David N., et al.
Publicado: (2009)

Cubosome nanoparticles potentiate immune properties of immunostimulants
por: Liu, Zhenguang, et al.
Publicado: (2016)

Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms
por: Torrealba, Débora, et al.
Publicado: (2016)

Immunostimulating Commensal Bacteria and Their Potential Use as Therapeutics
por: McCuaig, Bonita, et al.
Publicado: (2023)

Intra-Peritoneal Hyperthermia Combining α-Galactosylceramide in the Treatment of Ovarian Cancer
por: Wu, Chao-Chih, et al.
Publicado: (2013)

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota
por: Wieland Brown, Laura C., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2sn4s3mqgrikpp7tce3csbkgqn