Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

We recently developed base editing, a genome-editing approach that enables the programmable conversion of one base pair into another without double-stranded DNA cleavage, excess stochastic insertions and deletions, or dependence on homology-directed repair. The application of base editing is limited...

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Detalles Bibliográficos
Autores principales: Rees, Holly A., Komor, Alexis C., Yeh, Wei-Hsi, Caetano-Lopes, Joana, Warman, Matthew, Edge, Albert S. B., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467206/
https://www.ncbi.nlm.nih.gov/pubmed/28585549
http://dx.doi.org/10.1038/ncomms15790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467206/
https://www.ncbi.nlm.nih.gov/pubmed/28585549
http://dx.doi.org/10.1038/ncomms15790

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