Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autoph...

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Detalles Bibliográficos
Autores principales: Sergin, Ismail, Evans, Trent D., Zhang, Xiangyu, Bhattacharya, Somashubhra, Stokes, Carl J., Song, Eric, Ali, Sahl, Dehestani, Babak, Holloway, Karyn B., Micevych, Paul S., Javaheri, Ali, Crowley, Jan R., Ballabio, Andrea, Schilling, Joel D., Epelman, Slava, Weihl, Conrad C., Diwan, Abhinav, Fan, Daping, Zayed, Mohamed A., Razani, Babak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467270/
https://www.ncbi.nlm.nih.gov/pubmed/28589926
http://dx.doi.org/10.1038/ncomms15750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467270/
https://www.ncbi.nlm.nih.gov/pubmed/28589926
http://dx.doi.org/10.1038/ncomms15750

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