HLA Class Ia and Ib Polyreactive Anti-HLA-E IgG2a Monoclonal Antibodies (TFL-006 and TFL-007) Suppress Anti-HLA IgG Production by CD19+ B Cells and Proliferation of CD4+ T Cells While Upregulating Tregs

The anti-HLA-E IgG2a mAbs, TFL-006 and TFL-007, reacted with all HLA-I antigens, similar to the therapeutic preparations of IVIg. Indeed, IVIg lost its HLA reactivity, when its HLA-E reactivity was adsorbed out. US-FDA approved IVIg to reduce antibodies in autoimmune diseases. But the mechanism unde...

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Detalles Bibliográficos
Autor principal: Ravindranath, Mepur H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467321/
https://www.ncbi.nlm.nih.gov/pubmed/28634589
http://dx.doi.org/10.1155/2017/3475926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467321/
https://www.ncbi.nlm.nih.gov/pubmed/28634589
http://dx.doi.org/10.1155/2017/3475926

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