Gain‐of‐function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells

Gain‐of‐function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor‐initiating cell functions. We determined t...

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Detalles Bibliográficos
Autores principales: Vaughan, Catherine A., Singh, Shilpa, Grossman, Steven R., Windle, Brad, Deb, Swati Palit, Deb, Sumitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467493/
https://www.ncbi.nlm.nih.gov/pubmed/28423230
http://dx.doi.org/10.1002/1878-0261.12068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467493/
https://www.ncbi.nlm.nih.gov/pubmed/28423230
http://dx.doi.org/10.1002/1878-0261.12068

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