Demonstration of a potent RET transcriptional inhibitor for the treatment of medullary thyroid carcinoma based on an ellipticine derivative

Dominant-activating mutations in the RET (rearranged during transfection) proto-oncogene, which encodes a receptor tyrosine kinase, is often associated with the development of medullary thyroid carcinoma (MTC). The proximal promoter region of the RET gene consists of a guanine-rich sequence containi...

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Detalles Bibliográficos
Autores principales: Kumarasamy, Vishnu Muthuraj, Sun, Daekyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467785/
https://www.ncbi.nlm.nih.gov/pubmed/28498409
http://dx.doi.org/10.3892/ijo.2017.3994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467785/
https://www.ncbi.nlm.nih.gov/pubmed/28498409
http://dx.doi.org/10.3892/ijo.2017.3994

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