C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation

Activation of the FOXO transcription factor DAF-16 by reduced insulin/IGF signaling (IIS) is considered to be beneficial in C. elegans due to its ability to extend lifespan and to enhance stress resistance. In the germline, cell-autonomous DAF-16 activity prevents stem cell proliferation, thus actin...

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Detalles Bibliográficos
Autores principales: Qi, Wenjing, Yan, Yijian, Pfeifer, Dietmar, Donner v. Gromoff, Erika, Wang, Yimin, Maier, Wolfgang, Baumeister, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467913/
https://www.ncbi.nlm.nih.gov/pubmed/28549065
http://dx.doi.org/10.1371/journal.pgen.1006801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467913/
https://www.ncbi.nlm.nih.gov/pubmed/28549065
http://dx.doi.org/10.1371/journal.pgen.1006801

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