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A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases

PP2C phosphatases control biological processes including stress responses, development, and cell division in all kingdoms of life. Diverse regulatory domains adapt PP2C phosphatases to specific functions, but how these domains control phosphatase activity was unknown. We present structures represent...

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Detalles Bibliográficos
Autores principales: Bradshaw, Niels, Levdikov, Vladimir M, Zimanyi, Christina M, Gaudet, Rachelle, Wilkinson, Anthony J, Losick, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468089/
https://www.ncbi.nlm.nih.gov/pubmed/28527238
http://dx.doi.org/10.7554/eLife.26111