Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

XRCC4 and DNA Ligase 4 (LIG4) form a tight complex that provides DNA ligase activity for classical non-homologous end joining (the predominant DNA double-strand break repair pathway in higher eukaryotes) and is stimulated by XLF. Independently of LIG4, XLF also associates with XRCC4 to form filament...

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Detalles Bibliográficos
Autores principales: Normanno, Davide, Négrel, Aurélie, de Melo, Abinadabe J, Betzi, Stéphane, Meek, Katheryn, Modesti, Mauro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468090/
https://www.ncbi.nlm.nih.gov/pubmed/28500754
http://dx.doi.org/10.7554/eLife.22900

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468090/
https://www.ncbi.nlm.nih.gov/pubmed/28500754
http://dx.doi.org/10.7554/eLife.22900

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