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Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

XRCC4 and DNA Ligase 4 (LIG4) form a tight complex that provides DNA ligase activity for classical non-homologous end joining (the predominant DNA double-strand break repair pathway in higher eukaryotes) and is stimulated by XLF. Independently of LIG4, XLF also associates with XRCC4 to form filament...

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Detalles Bibliográficos
Autores principales:	Normanno, Davide, Négrel, Aurélie, de Melo, Abinadabe J, Betzi, Stéphane, Meek, Katheryn, Modesti, Mauro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468090/ https://www.ncbi.nlm.nih.gov/pubmed/28500754 http://dx.doi.org/10.7554/eLife.22900

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