Quantification of within-sample genetic heterogeneity from SNP-array data

Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement. There is therefore a need for tools to estimate ITH in individual samples, using stan...

Descripción completa

Detalles Bibliográficos
Autores principales: Martinez, Pierre, Kimberley, Christopher, BirkBak, Nicolai J., Marquard, Andrea, Szallasi, Zoltan, Graham, Trevor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468233/
https://www.ncbi.nlm.nih.gov/pubmed/28607403
http://dx.doi.org/10.1038/s41598-017-03496-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468233/
https://www.ncbi.nlm.nih.gov/pubmed/28607403
http://dx.doi.org/10.1038/s41598-017-03496-0

Ejemplares similares