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Quantification of within-sample genetic heterogeneity from SNP-array data

Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement. There is therefore a need for tools to estimate ITH in individual samples, using stan...

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Detalles Bibliográficos
Autores principales:	Martinez, Pierre, Kimberley, Christopher, BirkBak, Nicolai J., Marquard, Andrea, Szallasi, Zoltan, Graham, Trevor A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468233/ https://www.ncbi.nlm.nih.gov/pubmed/28607403 http://dx.doi.org/10.1038/s41598-017-03496-0

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