Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice

Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder characterized by extracellular deposits known as drusen. A major constituent of drusen deposits are Alzheimer disease-associated amyloid β (Aβ) peptides. To understand the etiology of Aβ proteostasis in AMD, w...

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Detalles Bibliográficos
Autores principales: Prasad, Tuhina, Zhu, Ping, Verma, Amrisha, Chakrabarty, Paramita, Rosario, Awilda M., Golde, Todd E., Li, Qiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468329/
https://www.ncbi.nlm.nih.gov/pubmed/28607377
http://dx.doi.org/10.1038/s41598-017-03397-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468329/
https://www.ncbi.nlm.nih.gov/pubmed/28607377
http://dx.doi.org/10.1038/s41598-017-03397-2

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