Cargando…

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice

Age-related macular degeneration (AMD) is a progressive retinal neurodegenerative disorder characterized by extracellular deposits known as drusen. A major constituent of drusen deposits are Alzheimer disease-associated amyloid β (Aβ) peptides. To understand the etiology of Aβ proteostasis in AMD, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prasad, Tuhina, Zhu, Ping, Verma, Amrisha, Chakrabarty, Paramita, Rosario, Awilda M., Golde, Todd E., Li, Qiuhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468329/ https://www.ncbi.nlm.nih.gov/pubmed/28607377 http://dx.doi.org/10.1038/s41598-017-03397-2

Ejemplares similares

A novel bispecific molecule delivered by recombinant AAV2 suppresses ocular inflammation and choroidal neovascularization
por: Li, Yiming, et al.
Publicado: (2017)

Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain
por: Chakrabarty, Paramita, et al.
Publicado: (2013)

Expression and cellular localization of the Mas receptor in the adult and developing mouse retina
por: Prasad, Tuhina, et al.
Publicado: (2014)

Microglia-specific targeting by novel capsid-modified AAV6 vectors
por: Rosario, Awilda M, et al.
Publicado: (2016)

Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
por: Chakrabarty, Paramita, et al.
Publicado: (2011)

Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
por: Chakrabarty, Paramita, et al.
Publicado: (2012)

Visual Function in Eyes with Intermediate AMD with and without Retinal Pigment Abnormalities
por: Schneck, Marilyn E., et al.
Publicado: (2021)

Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease
por: Golde, Todd E, et al.
Publicado: (2013)

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
por: Golde, Todd E, et al.
Publicado: (2013)

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
por: McFarland, Karen N, et al.
Publicado: (2021)

Alterations of retinal pigment epithelium cause AMD-like retinopathy in senescence-accelerated OXYS rats
por: Markovets, Anton M., et al.
Publicado: (2010)

Polarisation-sensitive OCT is useful for evaluating retinal pigment epithelial lesions in patients with neovascular AMD
por: Schütze, Christopher, et al.
Publicado: (2016)

Microstructure of the retinal pigment epithelium near-infrared autofluorescence in healthy young eyes and in patients with AMD
por: Vienola, Kari V., et al.
Publicado: (2020)

Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy
por: Das, Pritam, et al.
Publicado: (2006)

Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice
por: Ceballos-Diaz, Carolina, et al.
Publicado: (2015)

Contributions of age-related alterations of the retinal pigment epithelium and of glia to the AMD-like pathology in OXYS rats
por: Telegina, Darya V., et al.
Publicado: (2017)

AMD-Like Substrate Causes Epithelial Mesenchymal Transition in iPSC-Derived Retinal Pigment Epithelial Cells Wild Type but Not C3-Knockout
por: Chinchilla, Blanca, et al.
Publicado: (2021)

Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
por: Das, Pritam, et al.
Publicado: (2012)

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells
por: Nguyen, Tu, et al.
Publicado: (2023)

Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects
por: Guziewicz, Karina E., et al.
Publicado: (2013)

rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies
por: Croft, Cara L., et al.
Publicado: (2019)

Beneficial Effects of Combined AT(1) Receptor/Neprilysin Inhibition (ARNI) Versus AT(1) Receptor Blockade Alone in the Diabetic Eye
por: Prasad, Tuhina, et al.
Publicado: (2016)

Retinal Remodeling and Metabolic Alterations in Human AMD
por: Jones, Bryan W., et al.
Publicado: (2016)

Development of an inducible anti-VEGF rAAV gene therapy strategy for the treatment of wet AMD
por: Reid, Christopher A., et al.
Publicado: (2018)

Microglia in the Mouse Retina Alter the Structure and Function of Retinal Pigmented Epithelial Cells: A Potential Cellular Interaction Relevant to AMD
por: Ma, Wenxin, et al.
Publicado: (2009)

Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors
por: Flores‐Bellver, Miguel, et al.
Publicado: (2021)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Il-10 signaling reduces survival in mouse models of synucleinopathy
por: Cockey, Samuel G., et al.
Publicado: (2021)

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease
por: Chakrabarty, Paramita, et al.
Publicado: (2018)

Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci
por: Smith, Erin N., et al.
Publicado: (2019)

Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization
por: Wang, Haibo, et al.
Publicado: (2016)

Tear of Retinal Pigment Epithelium following YAG Laser Posterior Capsulotomy in a Patient on Anti-VEGF Treatment for AMD: Six Months’ Follow-Up
por: Vardarinos, Athanasios, et al.
Publicado: (2012)

Dabigatran and Wet AMD, Results From Retinal Pigment Epithelial Cell Monolayers, the Mouse Model of Choroidal Neovascularization, and Patients From the Medicare Data Base
por: Akter, Tanjina, et al.
Publicado: (2022)

Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity
por: Cheng, Pin-Nan, et al.
Publicado: (2012)

ANGIOTENSIN (1-7) EXPRESSING LACTOBACILLUS DOSE-DEPENDENTLY BENEFITS THE GUT-BRAIN AXIS IN AGED RATS
por: Sun, Yi, et al.
Publicado: (2019)

Automatic Detection of AMD and DME Retinal Pathologies Using Deep Learning
por: Saidi, Latifa, et al.
Publicado: (2023)

Normal cognition in transgenic BRI2-Aβ mice
por: Kim, Jungsu, et al.
Publicado: (2013)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
por: Dhillon, Jess-Karan S., et al.
Publicado: (2017)

Bioinspired polymeric pigments to mimic natural hair coloring
por: Sun, Yu, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_n0hvs2b20jg6r8nk220cv3fdqd