Novel Class IIa-Selective Histone Deacetylase Inhibitors Discovered Using an in Silico Virtual Screening Approach

Histone deacetylases (HDAC) contain eighteen isoforms that can be divided into four classes. Of these isoform enzymes, class IIa (containing HDAC4, 5, 7 and 9) target unique substrates, some of which are client proteins associated with epigenetic control. Class IIa HDACs are reportedly associated wi...

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Detalles Bibliográficos
Autores principales: Hsu, Kai-Cheng, Liu, Chang-Yi, Lin, Tony Eight, Hsieh, Jui-Hua, Sung, Tzu-Ying, Tseng, Hui-Ju, Yang, Jinn-Moon, Huang, Wei-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468338/
https://www.ncbi.nlm.nih.gov/pubmed/28607401
http://dx.doi.org/10.1038/s41598-017-03417-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468338/
https://www.ncbi.nlm.nih.gov/pubmed/28607401
http://dx.doi.org/10.1038/s41598-017-03417-1

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