Evaluation of AZD1446 as a Therapeutic in DYT1 Dystonia

DYT1 dystonia is an early-onset, hyperkinetic movement disorder caused by a deletion in the gene TOR1A, which encodes the protein torsinA. Several lines of evidence show that in animal models of DTY1 dystonia, there is impaired basal dopamine (DA) release and enhanced acetylcholine tone. Clinically,...

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Detalles Bibliográficos
Autores principales: Zimmerman, Chelsea N., Eskow Jaunarajs, Karen L., Meringolo, Maria, Rizzo, Francesca R., Santoro, Massimo, Standaert, David G., Pisani, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468415/
https://www.ncbi.nlm.nih.gov/pubmed/28659770
http://dx.doi.org/10.3389/fnsys.2017.00043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468415/
https://www.ncbi.nlm.nih.gov/pubmed/28659770
http://dx.doi.org/10.3389/fnsys.2017.00043

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