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Differential Fasting Plasma Glucose and Ketone Body Levels in GHRKO versus 3xTg-AD Mice: A Potential Contributor to Aging-Related Cognitive Status?

Cognitive function declines with age and appears to correlate with decreased cerebral metabolic rate (CMR). Caloric restriction, an antiaging manipulation that extends life-span and can preserve cognitive function, is associated with decreased glucose uptake, decreased lactate levels, and increased...

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Detalles Bibliográficos
Autores principales: Griffith, Chelsea M., Macklin, Lauren N., Bartke, Andrzej, Patrylo, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468562/
https://www.ncbi.nlm.nih.gov/pubmed/28638409
http://dx.doi.org/10.1155/2017/9684061