A C9ORF72 BAC mouse model recapitulates key epigenetic perturbations of ALS/FTD

BACKGROUND: Amyotrophic Lateral Sclerosis (ALS) is a fatal and progressive neurodegenerative disorder with identified genetic causes representing a significant minority of all cases. A GGGGCC hexanucleotide repeat expansion (HRE) mutation within the C9ORF72 gene has recently been identified as the m...

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Detalles Bibliográficos
Autores principales: Esanov, Rustam, Cabrera, Gabriela Toro, Andrade, Nadja S., Gendron, Tania F., Brown, Robert H., Benatar, Michael, Wahlestedt, Claes, Mueller, Christian, Zeier, Zane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468954/
https://www.ncbi.nlm.nih.gov/pubmed/28606110
http://dx.doi.org/10.1186/s13024-017-0185-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468954/
https://www.ncbi.nlm.nih.gov/pubmed/28606110
http://dx.doi.org/10.1186/s13024-017-0185-9

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