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Effects of local and spinal administrations of mu-opioids on postoperative pain in aged vs adult mice
INTRODUCTION: Suboptimal management of postoperative pain leads to increased risk of chronic opioid therapy, especially in elderly patients. OBJECTIVES: Although this age-dependent phenomenon has been observed clinically, basic mechanisms including baseline nociception, postoperative hypersensitivit...
Autores principales: | Mecklenburg, Jennifer, Patil, Mayur J., Koek, Wouter, Akopian, Armen N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469295/ https://www.ncbi.nlm.nih.gov/pubmed/28626834 http://dx.doi.org/10.1097/PR9.0000000000000584 |
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