The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

PrP(C), the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrP(Sc), the infectious isoform, but how this occurs is mysterious. Here, using a combination of electrophysiological, cellular, and biophysical techniques, we show that the flexible, N-terminal domain o...

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Detalles Bibliográficos
Autores principales: Wu, Bei, McDonald, Alex J, Markham, Kathleen, Rich, Celeste B, McHugh, Kyle P, Tatzelt, Jörg, Colby, David W, Millhauser, Glenn L, Harris, David A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469617/
https://www.ncbi.nlm.nih.gov/pubmed/28527237
http://dx.doi.org/10.7554/eLife.23473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469617/
https://www.ncbi.nlm.nih.gov/pubmed/28527237
http://dx.doi.org/10.7554/eLife.23473

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