Cargando…

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus

PrP(C), the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of PrP(Sc), the infectious isoform, but how this occurs is mysterious. Here, using a combination of electrophysiological, cellular, and biophysical techniques, we show that the flexible, N-terminal domain o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Bei, McDonald, Alex J, Markham, Kathleen, Rich, Celeste B, McHugh, Kyle P, Tatzelt, Jörg, Colby, David W, Millhauser, Glenn L, Harris, David A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469617/ https://www.ncbi.nlm.nih.gov/pubmed/28527237 http://dx.doi.org/10.7554/eLife.23473

Ejemplares similares

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus
por: Rösener, Nadine S., et al.
Publicado: (2020)

Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions
por: Sánchez-López, Carolina, et al.
Publicado: (2018)

Cotranslational Protein Folding and Terminus Hydrophobicity
por: Srivastava, Sheenal, et al.
Publicado: (2011)

Anmerkungen zum Terminus „Drainage“
por: Böttcher, Arne, et al.
Publicado: (2022)

Streptophyte phytochromes exhibit an N-terminus of cyanobacterial origin and a C-terminus of proteobacterial origin
por: Buchberger, Thorsten, et al.
Publicado: (2015)

Albumin Fusion at the N-Terminus or C-Terminus of HM-3 Leads to Improved Pharmacokinetics and Bioactivities
por: Li, Ting, et al.
Publicado: (2021)

Single‐residue posttranslational modification sites at the N‐terminus, C‐terminus or in‐between: To be or not to be exposed for enzyme access
por: Sirota, Fernanda L., et al.
Publicado: (2015)

Functional Interactions between KCNE1 C-Terminus and the KCNQ1 Channel
por: Chen, Jerri, et al.
Publicado: (2009)

Improving the catalytic characteristics of phenolic acid decarboxylase from Bacillus amyloliquefaciens by the engineering of N-terminus and C-terminus
por: Li, Qin, et al.
Publicado: (2021)

The structure of songbird MHC class I reveals antigen binding that is flexible at the N-terminus and static at the C-terminus
por: Eltschkner, Sandra, et al.
Publicado: (2023)

A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT
por: Talavera, Ariel, et al.
Publicado: (2019)

The N terminus of α-synuclein dictates fibril formation
por: McGlinchey, Ryan P., et al.
Publicado: (2021)

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury
por: Jiang, Jingbo, et al.
Publicado: (2019)

The role of the carboxyl terminus in folding of the serotonin transporter
por: El-Kasaby, Ali, et al.
Publicado: (2010)

Solid Phase Formylation of N-Terminus Peptides
por: Tornesello, Anna Lucia, et al.
Publicado: (2016)

Proust considéré comme terminus : suivi de Stendhal, Balzac, Flaubert, Zola /
por: Gracq, Julien, 1910-2007
Publicado: (1986)

APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus
por: Mavylutov, Timur, et al.
Publicado: (2017)

A Conserved Function for the H2A.Z C Terminus
por: Wratting, Daniel, et al.
Publicado: (2012)

The RAG2 C-terminus suppresses genomic instability and lymphomagenesis
por: Deriano, Ludovic, et al.
Publicado: (2011)

Rpb3 promotes hepatocellular carcinoma through its N-terminus
por: Fang, Zhe-Ping, et al.
Publicado: (2014)

Structural and Functional Insights into the N-Terminus of Schizosaccharomyces pombe Cdc5
por: Collier, Scott E., et al.
Publicado: (2014)

Importance of the carboxyl terminus for folding and trafficking of the serotonin transporter
por: El-Kasaby, Ali, et al.
Publicado: (2009)

The N-terminus of mature human frataxin is intrinsically unfolded
por: Prischi, Filippo, et al.
Publicado: (2009)

New insight into the structure and function of Hfq C-terminus
por: Fortas, Emilie, et al.
Publicado: (2015)

A mechanism for exocytotic arrest by the Complexin C-terminus
por: Makke, Mazen, et al.
Publicado: (2018)

The C terminus of p73 is essential for hippocampal development
por: Amelio, Ivano, et al.
Publicado: (2020)

Terminus-Associated Non-coding RNAs: Trash or Treasure?
por: Ni, Wen-Juan, et al.
Publicado: (2020)

Copper-mediated peptide arylation selective for the N-terminus
por: Miller, Mary K., et al.
Publicado: (2020)

Exploiting Protein N-Terminus for Site-Specific Bioconjugation
por: De Rosa, Lucia, et al.
Publicado: (2021)

A novel motif in the NaTrxh N-terminus promotes its secretion, whereas the C-terminus participates in its interaction with S-RNase in vitro
por: Ávila-Castañeda, Alejandra, et al.
Publicado: (2014)

Mitochondrial localization of Dictyostelium discoideum dUTPase mediated by its N-terminus
por: Chia, Catherine P., et al.
Publicado: (2020)

Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog
por: Tolani, Bhairavi, et al.
Publicado: (2018)

Insight into the Antifungal Mechanism of Action of Human RNase N-terminus Derived Peptides
por: Salazar, Vivian A., et al.
Publicado: (2019)

Pro-apoptotic protein–protein interactions of the extended N-AChE terminus
por: Toiber, Debra, et al.
Publicado: (2009)

The far C-terminus of MCAK regulates its conformation and spindle pole focusing
por: Zong, Hailing, et al.
Publicado: (2016)

Long range recognition and selection in IDPs: the interactions of the C-terminus of p53
por: Kannan, Srinivasaraghavan, et al.
Publicado: (2016)

Regulation of Bestrophin Cl Channels by Calcium: Role of the C Terminus
por: Xiao, Qinghuan, et al.
Publicado: (2008)

Analysis of Notch Lacking the Carboxyl Terminus Identified in Drosophila Embryos
por: Wesley, Cedric S., et al.
Publicado: (2000)

The C terminus of talin links integrins to cell cycle progression
por: Wang, Pengbo, et al.
Publicado: (2011)

Flip-flop around the origin and terminus of replication in prokaryotic genomes
por: Mackiewicz, Paweł, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_cpbao1ke17skroevf3qh9m6rcl