Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

Cardiac β-myosin variants cause hypertrophic (HCM) or dilated (DCM) cardiomyopathy by disrupting sarcomere contraction and relaxation. The locations of variants on isolated myosin head structures predict contractility effects but not the prominent relaxation and energetic deficits that characterize...

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Detalles Bibliográficos
Autores principales: Alamo, Lorenzo, Ware, James S, Pinto, Antonio, Gillilan, Richard E, Seidman, Jonathan G, Seidman, Christine E, Padrón, Raúl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Human Biology and Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469618/
https://www.ncbi.nlm.nih.gov/pubmed/28606303
http://dx.doi.org/10.7554/eLife.24634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469618/
https://www.ncbi.nlm.nih.gov/pubmed/28606303
http://dx.doi.org/10.7554/eLife.24634

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