FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts

In kidney disease, higher circulating levels of the mineral-regulating hormone fibroblast growth factor (FGF)-23 are predictive of disease progression but direct pathogenic effects on the kidney are unknown. We sought evidence of local renal synthesis in response to unilateral ureteric obstruction i...

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Detalles Bibliográficos
Autores principales: Smith, Edward R., Tan, Sven-Jean, Holt, Stephen G., Hewitson, Tim D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469734/
https://www.ncbi.nlm.nih.gov/pubmed/28611350
http://dx.doi.org/10.1038/s41598-017-02709-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469734/
https://www.ncbi.nlm.nih.gov/pubmed/28611350
http://dx.doi.org/10.1038/s41598-017-02709-w

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