Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis

NZ17074 (N1), an arenicin-3 derivative isolated from the lugworm, has potent antibacterial activity and is cytotoxic. To reduce its cytotoxicity, seven N1 analogues with different structures were designed by changing their disulfide bonds, hydrophobicity, or charge. The “rocket” analogue-N2 and the...

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Detalles Bibliográficos
Autores principales: Yang, Na, Liu, Xuehui, Teng, Da, Li, Zhanzhan, Wang, Xiumin, Mao, Ruoyu, Wang, Xiao, Hao, Ya, Wang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469750/
https://www.ncbi.nlm.nih.gov/pubmed/28611436
http://dx.doi.org/10.1038/s41598-017-03664-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469750/
https://www.ncbi.nlm.nih.gov/pubmed/28611436
http://dx.doi.org/10.1038/s41598-017-03664-2

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