Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening

TNFα is a homotrimeric pro-inflammatory cytokine, whose direct targeting by protein biotherapies has been an undeniable success for the treatment of chronic inflammatory diseases. Despite many efforts, no orally active drug targeting TNFα has been identified so far. In the present work, we identifie...

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Detalles Bibliográficos
Autores principales: Mouhsine, Hadley, Guillemain, Hélène, Moreau, Gabriel, Fourati, Najla, Zerrouki, Chouki, Baron, Bruno, Desallais, Lucille, Gizzi, Patrick, Ben Nasr, Nesrine, Perrier, Julie, Ratsimandresy, Rojo, Spadoni, Jean-Louis, Do, Hervé, England, Patrick, Montes, Matthieu, Zagury, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469758/
https://www.ncbi.nlm.nih.gov/pubmed/28611375
http://dx.doi.org/10.1038/s41598-017-03427-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469758/
https://www.ncbi.nlm.nih.gov/pubmed/28611375
http://dx.doi.org/10.1038/s41598-017-03427-z

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