Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host

Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenecks impeding the wider use. Therefore, improvement in telome...

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Detalles Bibliográficos
Autores principales: Amagai, Keita, Ikeda, Haruo, Hashimoto, Junko, Kozone, Ikuko, Izumikawa, Miho, Kudo, Fumitaka, Eguchi, Tadashi, Nakamura, Takemichi, Osada, Hiroyuki, Takahashi, Shunji, Shin-ya, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469769/
https://www.ncbi.nlm.nih.gov/pubmed/28611443
http://dx.doi.org/10.1038/s41598-017-03308-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469769/
https://www.ncbi.nlm.nih.gov/pubmed/28611443
http://dx.doi.org/10.1038/s41598-017-03308-5

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