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Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host
Telomestatin, a strong telomerase inhibitor with G-quadruplex stabilizing activity, is a potential therapeutic agent for treating cancers. Difficulties in isolating telomestatin from microbial cultures and in chemical synthesis are bottlenecks impeding the wider use. Therefore, improvement in telome...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469769/ https://www.ncbi.nlm.nih.gov/pubmed/28611443 http://dx.doi.org/10.1038/s41598-017-03308-5 |