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JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis

Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated protein kinase or c-Jun N-terminal Kinase (SAPK/JNK) is a mole...

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Detalles Bibliográficos
Autores principales: Khan, Meraj A., Farahvash, Armin, Douda, David N., Licht, Johann-Christoph, Grasemann, Hartmut, Sweezey, Neil, Palaniyar, Nades
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469795/
https://www.ncbi.nlm.nih.gov/pubmed/28611461
http://dx.doi.org/10.1038/s41598-017-03257-z